Aronase inhibitors may increase the risk of the development of new cardiovascular disease, according to a new study, which was published in theJournal of the American College of Cardiology.
This is the third in a series of two randomized clinical trials that evaluated the use of a medication known as azithromycin for the treatment of acute myocardial infarction and acute coronary syndromes in adults. The first randomized trial, conducted by the National Institutes of Health in 2001, compared the efficacy of azithromycin with the treatment of angina with a beta-blocker. In a separate, larger study, researchers looked at the use of azithromycin and other antibiotics in patients with coronary artery disease. The first randomization included a comparison of three classes of antibiotics: amoxicillin, clarithromycin, and azithromycin.
The second trial, which enrolled a total of 5,976 adults in the United States, examined the effect of adding antibiotics to angina versus other drugs in the same group of patients with acute coronary syndromes. The first trial included 5,067 patients with acute coronary syndromes (as defined by the American College of Cardiology website: acute coronary syndromes) and compared the efficacy of adding antibiotics to an antibiotic regimen including amoxicillin, clarithromycin, and azithromycin. The second trial enrolled 1,051 patients with acute coronary syndromes and compared the efficacy of adding antibiotics to other drugs in the same group of patients with acute coronary syndromes.
The third randomized trial, which enrolled 1,050 patients with acute coronary syndromes and compared the efficacy of adding antibiotics to other drugs in the same group of patients with acute coronary syndromes, compared the efficacy of adding antibiotics to angina with angina in patients with both conditions.
A total of 4,837 patients with acute coronary syndromes and 1,749 with angina were randomized to receive a combination of azithromycin plus amoxicillin in a randomized double-blind, placebo-controlled design. In addition to amoxicillin, azithromycin also was added to a beta-blocker in addition to amoxicillin.
The investigators also looked at the effect of adding antibiotics to other antibiotics, including clarithromycin, to patients with both conditions, and compared the efficacy of adding antibiotics to angina with angina in patients with both conditions.
The researchers found that patients with acute coronary syndromes had a significantly greater benefit from adding amoxicillin to azithromycin, and that patients with acute coronary syndromes also had a significantly greater benefit from adding clarithromycin to azithromycin. However, patients with angina had a significantly greater benefit from adding clarithromycin to azithromycin.
“The combination of azithromycin with amoxicillin is an effective treatment for acute coronary syndromes, but it is not a treatment for angina,” said study investigator Dr. David A. Schmitz, PhD, a cardiologist at Northwestern University in Chicago, who was not involved in the current study.
Azithromycin is a macrolide antibacterial. The macrolide class of antibiotics is a broad-spectrum beta-lactamase inhibitor that has been used in the treatment of pneumonia and bacterial infections in adults.
The study was sponsored by Pfizer Inc., a division of Pfizer Inc. Its results were published in the February issue ofEuropean Journal of Clinical Pharmacology, and are published online February 24, 2002.
A Cochrane Review of the Results of the Trial 1 found no significant differences in the treatment of acute coronary syndromes in patients treated with antibiotics compared with other drugs in the same group of patients with acute coronary syndromes. However, patients with angina had a significantly greater benefit from azithromycin compared with patients with angina in the amoxicillin group. The researchers concluded that patients with angina had a significantly greater benefit from azithromycin, and that patients with angina had a significantly greater benefit from clarithromycin.
The investigators’ data also showed that adding antibiotics to angina was not associated with a higher risk of hospitalization for cardiovascular disease or death. Patients with angina had a significantly greater risk of hospitalization for cardiovascular disease or death, which was similar to those with acute coronary syndromes.
“This is the first randomized controlled trial to evaluate the safety of adding antibiotics to angina to patients with acute coronary syndromes,” said Schmitz.
Zithromax has been shown to cause some side effects. Talk to your health care provider if these mild reactions do not go away within a few days.
Common side effects reported from Zithromax use include:
This is not a complete list of adverse effects – though these are among the most common.Seek medical attention right away if you experience any of the following symptoms while taking Zithromax:
As with all prescription medication, be sure to inform the prescribing doctor about any medical conditions you have been previously diagnosed with and any medication/ supplements you are currently taking before starting treatment with Zithromax.
Zithromax can interact with other medications and substances, causing potentially serious side effects. These medications and substances include certain anticoagulants (blood thinners), colchicine (Colcrys, Gloperba, Mitigare), cyclosporine (Gengraf, Neoral, Sandimmune), digoxin (Lanoxin), dihydroergotamine (D. H. E. 45, Migranal, Trudhesa); ergotamine (Ergomar, in Migergot), medications for irregular heartbeat such as amiodarone (Nexterone, Pacerone), dofetilide (Tikosyn), procainamide, quinidine, and sotalol (Betapace, Sorine, Sotylize), nelfinavir (Viracept), and phenytoin (Dilantin, Phenytek).
Certain antacids can reduce the effectiveness of Zithromax tablets and Zithromax powder, so you should allow time between taking antacids and your Zithromax dose.
In addition, let your doctor know if you are pregnant or planning on becoming pregnant before starting treatment with this medication.
What are Zithromax tablets and Zithromax Powder? Zithromax is a medication used to treat bacterial infections (sc FILE/Getty Images) What are the differences? Zithromax tablets and Zithromax are almost always the same medication. Zithromax contains Azithromycin, a macrolide antibiotic that works by stopping the growth of bacteria. Zithromax is used to treat a variety of bacterial infections, including respiratory infections, urinary tract infections, skin infections, and sexually transmitted infections. Zithromax powder contains a blend of ingredients that make Zithromax hard to swallow and therefore can be dangerous to take. Zithromax is also often used in combination with other medications (eg, Coumadin, etc) to treat certain types of arthritis, including rheumatoid arthritis.While these medications have been shown to interact, they can increase the risk of certain side effects. Zithromax is also associated with an increased risk of tendon rupture, although this is uncommon. Additionally, Zithromax can cause dizziness and drowsiness in some people. In addition, Zithromax can cause diarrhea and gas with a highortality rate. It is crucial to let your doctor know if you are taking any of these medications while taking Zithromax.
In addition, let your doctor know if you are taking (Zithromax Pro, Zithromax Zydone, Zithromax Zydone Extended Release, etc). If you have any pre-existing medical conditions, you should not take this medication unless you are prescribed one.
Zithromax Zithromax Pro contains Azithromycin, a macrolide antibiotic that works by stopping the growth of bacteria.
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Zithromax (Azithromycin) is a medication that can only be purchased with a doctors prescription. While processing your order for the medication, it is necessary to get a valid prescription from your doctor The prescription can be scanned, emailed, or uploaded at liferxpharmacy.com or fax on +1-800-986-4751 Alternatively, if you like, we can even contact your doctor to obtain a valid prescription.
The maximum amount of Zithromax (Azithromycin) can be ordered at one time is a 90-day supply. The amount that can be ordered is dependent on the instructions and quantity mentioned on your medical prescription. Refilling alternate is always available for future needs.
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Zithromax (Azithromycin) is available in both generic and brand form. Generic medicines contain the same active components as brand-name pharmaceuticals have. They ensure and meet the same quality, strength, and purity standards in comparison to any other brand.
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Approved medicationsAzithromycin, the active ingredient in Zithromax (Azithromycin), is... is a prescription medicine. It is a type of medicine called a azalcin or other antibiotic. Azithromycin belongs to a class of drugs called antibiotics. It works by stopping the growth of...
LifeRx pharmacy makes it simple to order your medicine for Zithromax (Azithromycin) online. With our Zithromax (Azithromycin) online shopping cart, you can easily place a refill option available online. Alternatively, if you are interested in ordering your medicine from us, we can send a message with our live chat contact us email address and askedWolf Pharmacy ([email protected] and would be more...
RecoverZithromax (azithromycin)is an antibiotic that belongs to theAZITHROMYCINfamily and is used to treat various infections caused by bacteria.is usually taken in the form of oral tabletsor as a liquid suspensionZithromax (Azithromycin)or as a tablet.may be takenwith or without foodwithout the use of amacron of food.
Treatment of bacterial infections
Bacterial infections affect the cells of the body. They also affect other organs such as the stomach and intestines.
Dosage and administration
The dose of Zithromax depends on the type of infection. The usual adult dose is 200mg every 4 to 6 hours as needed for bacterial infections. Children's doses are usually smaller, and more convenient. The usual adult dose is 400mg a day. Doses of children's Zithromax is usually higher and should be used under medical supervision.
The duration of treatment is determined by the severity of the infection. For conditions like ear infections, certain antibiotics are recommended for short durations. For conditions such as sinusitis, a course of antibiotic therapy is usually recommended. If a course of therapy is not possible or appropriate, the course of antibiotic therapy may be recommended.
The dosage of Zithromax (azithromycin) depends on the type of infection. The usual adult dose is 200mg every 4 hours as needed for bacterial infections.
It is not recommended to take more than the recommended dose of Zithromax (azithromycin) in a day.
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